![]() She reported that she had a healthy lifestyle and did not have any health-related problems. As the patient had a mild form of the disease, she was treated only with vitamin supplements. Other members of her family had also tested positive for SARS-CoV-2 infection around the same time. Case Reportīased on the clinical, laboratory, and reverse transcription polymerase chain reaction (PCR-RT) data of a nasopharyngeal swab sample, she had a positive result for SARS-CoV-2 infection. The purposes of this paper are to present a case of a 27-year-old woman who developed amenorrhea after recovering from SARS-CoV-2 infection and to draw attention to clinicians to follow COVID-19 patients for a long time, and they need to pay attention to menstrual disturbances, especially in young female patients. However, the expression of ACE2 is very low in stromal and perivascular cells of the ovarian cortex, while its expression is highest in the endothelium, lungs, kidney, and the heart. ![]() There is evidence that the renin-angiotensin-aldosterone system is involved in female reproductive processes such as folliculogenesis, steroidogenesis, oocyte maturation, and ovulation. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor for entry into cells. According to a PubMed search with the keywords “ovarian insufficiency, COVID-19” and literature review conducted on September 28, 2021, limited clinical cases have been published on the effects of the virus on the female reproductive system. However, there are only a limited number of publications on the effect of SARS-CoV-2 infection on the ovaries. In addition to the typical cases, there have been a large number of reports on atypical forms or presentations of the disease and related complications. Its effects on the respiratory, cardiac, neurological, hematopoietic, gastrointestinal, muscle-skeletal, cutan, ocular, and urological systems are now well known. Although SARS-CoV-2 infection is primarily a respiratory disease, it affects various systems and organs throughout the body. SARS-CoV-2 has spread worldwide and in the end of 2021 more than over 278 million cases and just under 5.4 million deaths have been reported globally, while the number of both confirmed and fatal cases is continually increasing. The symptoms and manifestations of this infection are complicated and vary widely, and have posed a huge challenge. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection was an unprecedented pandemic that spread rapidly and widely across the globe. Keywords: SARS-CoV-2 infection Premature ovarian Ovary Women fertility Atypical manifestations Introduction More evidence, through both epidemiologic and clinical studies, as well as long-term follow-up studies, is needed to understand the impact of this infection on the human ovary, especially in reproductive-aged women. Coronavirus disease 2019 (COVID-19) patients need to be followed up for a long time, and clinicians need to pay attention to menstrual disturbances, especially in young female patients. In particular, the potential adverse effects of SARS-CoV-2 infection on fertility are unclear. Till now there are limited publications on the effect of SARS-CoV-2 infection on the ovaries. Based on clinical, laboratory, and reverse transcription polymerase chain reaction (RT-PCR) data of a nasopharyngeal swab sample, she had a positive result for SARS-CoV-2 infection. The patient had a sub-febrile temperature, myalgia, fatigue, sweating, loss of appetite, and mild sleep disorder. She had fever on the second day of the menstrual cycle, and her cycle had been interrupted on the same day. A 27-year-old female patient presented with amenorrhea. Our aims are to describe a unique case that developed amenorrhea during and after SARS-CoV-2 infection and to push researchers to do more researches to understand the effects of SARS-CoV-2 infection on the ovaries. ![]() Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is known to have a wide spectrum of effects on the respiratory, cardiac, neurological, hematopoietic, gastrointestinal, ocular and urological systems, but there is very little information on its effects on the human ovary. ![]()
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